利伐沙班与低分子肝素对髋关节置换患者凝血功能的影响

目的 对比观察利伐沙班与低分子肝素对髋关节置换患者凝血功能的影响.方法 选取上海交通大学附属第一人民医院松江分院2019年行髋关节置换术治疗的90例患者作为研究对象,采用随机数余数分组法分为低分子肝素组(45例)和利伐沙班组(45例),低分子肝素组患者采用低分子肝素治疗,利伐沙班组患者采用利伐沙班治疗,对两组患者凝血功...

Effects of rivaroxaban and low-molecular-weight heparin on coagulation function in patients with hip replacement

Objective To compare the effects of rivaroxaban and low-molecular-weight heparin on coagulation function in patients with hip replacement.Methods A total of 90 patients who underwent hip arthroplasty in First Affiliated Hospital of Shanghai Jiao Tong University Songjiang Branch Institute in 2019 were selected as the research subjects.They were divided into the low-molecular-weight heparin group(45 cases)and the rivaroxaban group(45 cases)by random number remainder grouping method.The low-molecular-weight heparin group was treated with low-molecular-weight heparin,and the rivaroxaban group was treated with rivaroxaban.The coagulation function,blood loss,postoperative drainage volume,and complication rate were compared between the two groups.Results There was no significant difference in blood loss and postoperative drainage volume between the rivaroxaban group and the low-molecular-weight heparin group(P>0.05).There was no significant difference in blood coagulation function indexes before the operation and 5 weeks after the operation in both groups(P>0.05),but the blood coagulation function indexes at 5 weeks after the operation were increased compared with those before the operation,and the differences were statistically significant(P<0.05).The incidence rate of complications in the rivaroxaban group was 2.22%,which was lower than 11.11%in low-molecular-weight heparin group,and the difference was statistically significant(P<0.05).Conclusion Both rivaroxaban and low-molecular-weight heparin can improve coagulation function in patients with hip replacement.However,rivaroxaban is more effective in reducing the incidence of complications and is worthy of popularization in future clinical work.