HMGB1和PSA联合检测对前列腺癌诊断价值的研究

目的 探讨高迁移率族蛋白1(HMGB1)和前列腺特异性抗原(PSA)联合检测对前列腺癌(PCa)的诊断价值.方法 选取在陆军第八十三集团军医院确诊为PCa和良性前列腺增生(BPH)的患者各60例,以及同期男性体检健康者60例,分别纳为PCa组、BPH组和对照组.检测3组的HMGB1和PSA水平,比较各组的HMGB1和P...

Study the value of combined detection of HMGB1 and PSA in the diagnosis of prostate cancer

Objective To investigate the diagnostic value of combined detection of high mobility group box-1 protein(HMGB1)and prostate specific antigen(PSA)for prostate cancer(PCa).Methods In the People′s Liberation Army Hospital of the 83rd Army Group,a total of 60 patients with PCa,60 patients benign prostatic hyperplasia(BPH)and 60 healthy males who had a physical examination during the same period were selected as PCa group,BPH group and control group,respectively.The levels of HMGB1 and PSA in three groups were detected,and the differences of HMGB1 and PSA levels among the three groups were compared.The receiver operating characteristic(ROC)area under the curve(AUC)was used to analyze the diagnostic efficacy of HMGB1 and PSA for PCa.Results The differences in serum HMGB1 and PSA levels among the 3 groups were statistically significant(P<0.05);Pairwise comparison among the 3 groups,the levels of HMGB1 and PSA in the PCa group and BPH group were higher than those in the control group,and the levels of HMGB1 and PSA in the PCa group were higher than those in the BPH group(P<0.05).The AUC of HMGB1 for diagnosing PCa was 0.7742,the sensitivity was 84.2%,the specificity was 73.0%,and the Youden index was 0.572;The AUC of PSA for diagnosing PCa was 0.8617,the sensitivity was 66.7%,the specificity was 82.1%,and the Youden index was 0.488;The AUC of the two combined detection and diagnosis of PCa was 0.8813,the sensitivity was 90.1%,the specificity was 71.7%,and the Youden index was 0.618.Conclusion The combined detection of HMGB1 and PSA can improve the diagnostic performance of PCa.