血清STIP-1、CA125a和CA125b诊断子宫腺肌病的临床价值

目的观察血清磷酸化应激诱导蛋白1(STIP-1)、CA125a和CA125b对子宫腺肌病的诊断价值。方法选择2018年1月至2019年12月在该院就诊、病理确诊为子宫腺肌病的患者93例为子宫腺肌病组。选择同期在该院健康体检者49例为健康对照组。观察两组研究对象血清STIP-1、CA125a、CA125b和CA125水平的变化及对子宫腺肌病的诊断效能;观察血清STIP-1、CA125a和CA125b水平与子宫腺肌病严重程度、痛经的关系,以及STIP-1、CA125a和CA125b之间的相关性。结果子宫腺肌病组患者血清STIP-1、CA125a、CA125b和CA125水平明显高于健康对照组(P<0.01)。血清STIP-1、CA125a和CA125b水平对子宫腺肌病的诊断效能明显优于CA125(P<0.05);STIP-1、CA125a、CA125b三者联合检测的灵敏度为94.6%,特异度为91.8%,受试者工作特征曲线下面积(AUC)为0.975,均明显高于STIP-1、CA125a和CA125b单项检测,而STIP-1、CA125a和CA125b3项单项检测的灵敏度、特异度、AUC差异均无统计学意义(P>0.05)。子宫腺肌病患者血清STIP-1、CA125a和CA125b水平随着病理分级升高而升高,有痛经的患者血清STIP-1、CA125a和CA125b水平高于无痛经的患者(P<0.05)。子宫腺肌病患者血清STIP-1水平与CA125a(r=0.761,P<0.01)和CA125b水平(r=0.814,P<0.01)呈正相关,而CA125a水平与CA125b水平呈正相关(r=0.786,P<0.01)。结论血清STIP-1、CA125a和CA125b参与了子宫腺肌病的病理生理过程,在诊断子宫腺肌病时具有较高的诊断效能,值得临床推广。

Clinical value of serum STIP-1,CA125a and CA125b in diagnosis of adenomyosis

Objective To observe the diagnostic value of serum stress-induced phosphoprotein 1(STIP-1),CA125a and CA125b in adenomyosis.Methods A total of 93 patients with pathologically diagnosed adenomyosis treated in this hospital from January 2018 to December 2019 were selected as the adenomyosis group.Forty-nine people undergoing healthy physical examination the in this hospital at the same period were selected as the healthy control group.The changes of serum STIP-1,CA125a,CA125b and CA125 levels were observed in the two groups,their diagnostic efficiency in the adenomyosis was also observed,the relationship between the serum levels of STIP-1,CA125a and CA125b with the severity of adenomyosis and dysmenorrhea and the relationship among STIP-1,CA125a and CA125b was observed.Results The levels of serum STIP-1,CA125a,CA125b and CA125 in the adenomyosis group were significantly higher than those in the healthy control group(P<0.01).The efficiency of serum STIP-1,CA125a and CA125b levels for diagnosing adenomyosis was significantly better than that of CA125(P<0.05).The sensitivity of combined detection of STIP-1,CA125a and CA125b was 94.6%,specificity was 91.8%,and AUC was 0.975,which were significantly higher than those of STIP-1,CA125a and CA125b single detection,and there was no statistically significantly difference in the sensitivity,specificity and AUC of STIP-1,CA125a and CA125b single detection(P>0.05).The levels of serum STIP-1,CA125a and CA125b in the patients with adenomyosis were increased with the increase of pathological grade,and their levels were higher than those in the patients with non-dysmenorrhea(P<0.05).The serum STIP-1 level in the patients with adenomyosis was positively correlated with CA125a(r=0.761,P<0.01)and CA125b(r=0.814,P<0.01),and CA125a was positively correlated with CA125b(r=0.786,P<0.01).Conclusion Serum STIP-1,CA125a and CA125b are involved in the pathophysiological process of adenomyosis,and have a high diagnostic efficiency in the diagnosis of adenomyosis,which is worthy of clinical promotion.