金凤丸联合氯米芬治疗PCOS合并不孕患者的疗效及对雄激素水平的影响

目的 观察金凤丸联合氯米芬治疗多囊卵巢综合征(PCOS)合并不孕患者的疗效及对雄激素水平的影响.方法 选择2017年1月至2019年12月在该院诊治的PCOS合并不孕患者96例,根据随机数字表法将患者分为观察组和对照组,每组48例.对照组予以氯米芬治疗,观察组在对照组的基础上予以金凤丸治疗.比较两组的疗效、排卵率、妊娠...

Therapeutic effect of Jinfeng Pill combined with clomiphene treatment in patients with polycystic ovary syndrome complicating infertility and its impact on androgen

Objective To observe the treatment efficacy of Jinfeng Pill combined with clomiphene in the patients with polycystic ovary syndrome(PCOS)complicating infertility and its impact on the androgen level.Methods Ninety-six patients with PCOS complicating infertility diagnosed and treated in this hospital from January 2017 to December 2019 were selected and divided into the observation group and control group according to random number table method,48 cases in each group.The control group was given clomiphene,and the observation group was given Jinfeng Pill on the basis of the control group.The efficacy,ovulation rate,pregnancy rate and adverse reaction occurrence rate were compared between two groups,and the body mass index(BMI),menstrual cycle,acne score,Ferriman-Gallway(F-G)score,ovarian volume,endometrial thickness,sectional follicle counts,ovarian interstitial area(SA)/total ovarian area(TA),testosterone,dehydroepiandrosterone sulfate(DHEAS),androstenedione,and sex hormone-binding globulin(SHBG)levels before and after treatment were compared between two groups.Results The total effective rate was 89.58%in the observation group and 70.83%in the control group,the observation group was significantly better than the control group(χ²=4.200,P<0.05).The pregnancy rate was 41.67%in the observation group,which was significantly higher than 16.67%in the control group(P<0.05),while the ovulation rate and incidence rate of adverse reactions had no statistical difference between two groups(P>0.05).There were no statistically significant differences in BMI,menstrual cycle,acne score,F-G score,ovarian volume,endometrial thickness,section follicle count,SA/TA,testosterone,DHEAS,androstenedione and SHBG levels before treatment between the two groups(P>0.05),after treatment the menstrual cycle in the two groups was shortened,ovarian volume was shrunk,BMI,acne score,F-G score,sectional follicle counts,SA/TA,testosterone,DHEAS and androstenedione levels were significantly reduced(P<0.05),while the endometrial thickness and SHBG levels in the two groups were significantly increased compared with those before treatment(P<0.05),and the improvement in the observation group were more obvious compared with the control group(P<0.05).Conclusion Jinfeng Pill combined with clomiphene has a significant efficacy on PCOS complicating infertility and can significantly increase the pregnancy rate.The mechanism may be related to Jinfeng Pill′s ability to reduce androgen levels.