妊娠期肝内胆汁淤积症412例临床分析

目的:观察妊娠期肝内胆汁淤积症对围生儿预后的影响及危害。方法:对本院412例住院分娩的妊娠期肝内胆汁淤积症病例进行回顾性分析,并与正常孕妇对照研究。结果:412例妊娠期肝内胆汁淤积症中早产97例占39.6%、胎儿宫内窘迫139例占33.7%、新生儿窒息56例占13.6%、产后出血63例占15.3%。对照组的早产27例占6.6%、胎儿宫内窘迫40例占9.7%、新生儿窒息24例占5.8%、产后出血31例占7.5%。两组各项发生率比较,P<0.01有显著差异。结论:妊娠期肝内胆汁淤积症严重影响围生儿的预后,应早期诊断,积极治疗,降低围生儿发病率及病死率。

Intrahepatic Cholestasis of Pregnancy:Clinical Analysis of 412 Cases

Objective:To observe the intrahepatic cholestasis of pregnancy on perinatal infant prognosis influence and harm. Methods:The 412 cases of hospital delivery of intrahepatic cholestasis of pregnancy were analyzed retrospecrively,and compared with normal pregnant women case-control study.Results:412 cases of intrahepatic cholestasis of pregnancy in 97 cases of premature accounted for 39.6%,139 cases of fetal distress in uterus accounted for 33.7%,56 cases of neonatal asphyxia accounted for 13.6%,63 cases of postpartum hemorrhage accounted for 15.3%.The control group of 27 cases of premature accounted for 6.6%,40 cases of fetal distress in uterus accounted for 9.7%,24 cases of neonatal asphyxia accounted for 5.8%,31 cases of postpartum hemorrhage accounted for 7.5%.Two groups of the comparison of the incidence of P<0.01 there is significant difference.Conclusion:In patients with intrahepatic cholestasis of pregnancy affect perinatal prognosis,early diagnosis,active treatment,to reduce perinatal morbidity and mortality rate.