| 甲磺酸伊马替尼有关物质的合成 |
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| 引用本文： | 吴立红,何元,张彦巧,张素娟,王宝玮. 甲磺酸伊马替尼有关物质的合成[J]. 中国医药工业杂志, 2011, 42(10) |
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| 作者姓名： | 吴立红 何元 张彦巧 张素娟 王宝玮 |
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| 作者单位： | 石药集团药物研究院,河北石家庄,050051 |
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| 摘 要： | 为了控制甲磺酸伊马替尼产品质量,分别合成了质量标准所载的5种有关物质:4-[(哌嗪-1-基)甲基]-N-[4-甲基-3-[ [4- (3-吡啶基)嘧啶-2-基]氨基]苯基]苯甲酰胺(A),4-[(4-甲基-1,4-二氧化哌嗪-1-基)甲基]-N-[4-甲基-3-[ [4- (3-吡啶基)嘧啶-2-基]氨基]苯基]苯甲酰胺(B),4-[(4-甲基-1-氧化哌嗪-1-基)甲基]-N-[4-甲基-3-[ [4- (3-吡啶基)嘧啶-2-基]氨基]苯基]苯甲酰胺(C),4-[ (4-甲基-4-氧化哌嗪-1-基)甲基]-N-[4-甲基-3-[ [4- (3-吡啶基)嘧啶-2-基]氨基]苯基]苯甲酰胺(D)和1,4-双[4-[4-甲基-3-[ [4- (3-吡啶基)嘧啶-2-基]氨基]苯基]氨甲酰基]苄基哌嗪(E),并经1H NMR、MS等确证结构.
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| 关 键 词： | 甲磺酸伊马替尼 有关物质 合成 |
Synthesis of Related Substances of Imatinib Mesylate |
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| WU Lihong,HE Yuan,ZHANG Yanqiao,ZHANG Sujuan,WANG Baowei. Synthesis of Related Substances of Imatinib Mesylate[J]. , 2011, 42(10) |
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| Authors: | WU Lihong HE Yuan ZHANG Yanqiao ZHANG Sujuan WANG Baowei |
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| Affiliation: | WU Lihong,HE Yuan,ZHANG Yanqiao,ZHANG Sujuan,WANG Baowei (Pharmaceutical Research Institute of Shijiazhuang Pharmaceutical Group Co.,Ltd.,Shijiazhuang 050051) |
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| Abstract: | To perform the quality control of imatinib mesylate,five related substances recorded in quality standard were prepared,and their structures were confirmed by ~1H NMR and MS.These substances were 4-[(piperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide(A), 4-[(4-methyl-1,4-dioxidopiperazin-1-yl)methyl]-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino] phenyl]benzamide(B),4-[(4-methyl-1-oxidopiperazin-1-yl) methyl]-N-[4-methyl-3-[[4-(pyridin-3-yl) pyrimidin-2 -yl]am... |
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| Keywords: | imatinib mesylate related substance synthesis |
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