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| 溶剂蒸发法和热熔挤出法制备苯扎贝特固体分散体 | |
| 引用本文： | 乔艳丽,黄雷鸣,赵琪,赵锦花. 溶剂蒸发法和热熔挤出法制备苯扎贝特固体分散体[J]. 中国医药工业杂志, 2011, 42(9): 660-664 |
| 作者姓名： | 乔艳丽 黄雷鸣 赵琪 赵锦花 |
| 作者单位： | 1. 天津大学药物科学与技术学院,天津,300072 2. 中国药科大学药物制剂教研室,江苏南京,210009 3. 天津天士力集团化学药物研究所,天津,300402 |
| 摘 要： | 以水难溶性药物苯扎贝特为模型药物,以聚维酮(PVP K30)或新型辅料Soluplus(R)为载体,分别采用溶剂法和热熔挤出法制备了苯扎贝特固体分散体.采用差示扫描量热法、傅里叶变换红外光谱法和X射线粉末衍射法对固体分散体进行了表征并考察了溶出度.结果显示,药物以无定形或分子状态存在于固体分散体中,两种工艺以及两种载体... |
| 关 键 词： | 固体分散体 苯扎贝特 溶剂法 热熔挤出法 |
Preparation of Bezafibrate Solid Dispersions by Solvent Evaporation and Hot-melt Extrusion Method |
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| QIAO Yanli,HUANG Leiming,ZHAO Qi,ZHAO Jinhua. Preparation of Bezafibrate Solid Dispersions by Solvent Evaporation and Hot-melt Extrusion Method[J]. , 2011, 42(9): 660-664 | |
| Authors: | QIAO Yanli HUANG Leiming ZHAO Qi ZHAO Jinhua |
| Affiliation: | QIAO Yanli~1,HUANG Leiming~2,ZHAO Qi~3,ZHAO Jinhua~(3*) (1.School of Pharmaceutical and Biotechnology,Tianjin University,Tianjin 300072,2.Dept.of Pharmaceutics,China Pharmaceutical University,Nanjing 210009,3.Chemical Drug R&D Center,Tasly Co.,Ltd.,Tianjin 300402) |
| Abstract: | The bezafibrate solid dispersions with PVP K30 or Soluplus~(?) as carrier were prepared by solvent evaporation or hot-melt extrusio method.The solid dispersions were characterized by differential scanning calorimetry (DSC),Fourier transform infrared spectroscopy(FT-IR) and powder X-ray diffraction(PXRD).The in vitro dissolutions of the prepared dispersions were also investigated.The results showed that bezafibrate existed as amorphous or molecule state in solid dispersions.The water solubility of bezafibrat... |
| Keywords: | solid dispersion bezafibrate solvent evaporation hot-melt extrusion |
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