| 胆碱酯酶复能剂治疗有机磷农药中毒的临床研究 |
| |
| 引用本文： | 宋文东. 胆碱酯酶复能剂治疗有机磷农药中毒的临床研究[J]. 中国医药导刊, 2011, 13(11): 1919-1920 |
| |
| 作者姓名： | 宋文东 |
| |
| 作者单位： | 江苏省徐州市第一人民医院急诊科,徐州,221002 |
| |
| 摘 要： | 目的:探讨应用胆碱酯酶复能剂治疗急性有机磷农药中毒(AOPP)的临床效果。方法:急性有机磷农药中毒76例,随机分成两组,静脉给予负荷量复能剂后,对照组37例短时间内重复给药不超过48h;治疗组39持续应用复能剂平均1周。结果:治疗组的胆碱酯酶活性及恢复时间明显优于对照组,两组的死亡率、阿托品的不良反应差异有显着性意义(P<0.05)。结论:早期、足量、反复、持续使用复能剂1周左右,可促进胆碱酯酶活性的恢复,减少阿托品的用量及不良反应,明显降低死亡率,提高临床疗效。
|
| 关 键 词： | 复能剂 有机磷中毒 治疗 胆碱酯酶活性 临床研究 |
Clinical Analysis of AOPP with the Cholinesterase Reactivator |
| |
| Song Wen-dong. Clinical Analysis of AOPP with the Cholinesterase Reactivator[J]. Chinese Journal of Medicinal Guide, 2011, 13(11): 1919-1920 |
| |
| Authors: | Song Wen-dong |
| |
| Affiliation: | Song Wen-dong (Department of Emergency,the First Affiliated People’s Hospital of Xuzhou Medical College,Jiangsu Province,Xuzhou 221002,China) |
| |
| Abstract: | Objective:To investigate the clinical effect of treatment with the reactivation agent of organophosphous pesticide, Methods:76 case of acute organophosphous pesticide were randomly divided into control group(n=39)and treatment group(n=60). The medicine was infused intermittendy in the control group within 48h,and infused continuously in treatment group for one week. Results:Compared with control group,Cholinesterase activity and recovery time in treatment group surpass in control group.Two groups have significant difference(P<0.05) in death rate,adverse effect of Atropine.Conclusion:The early treatment for organophosphous pesticide with the reactivmion agent of full dose and enough Course can promote me recovery of promote the recovery of ChE activity,and reduce dose of Atropine and adverse effect,greatly improve clinical effect and depress death rate. |
| |
| Keywords: | Reactivation agent Organophosphate poisoning Therapy ChE activity Clinical reaearch |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
