| 蝉花菌丝体对慢性肾功能衰竭大鼠的治疗作用 |
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| 引用本文： | 谢炜,郭月芳,盛雨辰. 蝉花菌丝体对慢性肾功能衰竭大鼠的治疗作用[J]. 中国医药工业杂志, 2011, 42(10) |
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| 作者姓名： | 谢炜 郭月芳 盛雨辰 |
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| 作者单位： | 中国医药工业研究总院上海医药工业研究院,上海,200437 |
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| 基金项目： | 国家“重大新药创制”科技重大专项 |
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| 摘 要： | 采用肾脏5/6切除和肾脏电灼建立慢性肾衰大鼠模型,考察蝉花菌丝体的治疗作用.结果表明,蝉花菌丝体的3个剂量组(0.6、1.2和2.4 g/kg)均能明显抑制肾脏5/6切除所致慢性肾衰大鼠血清中尿素氮和肌酐水平的升高,也能抑制由肾脏电灼引起慢性肾衰大鼠肌酐的升高.这提示蝉花菌丝体能有效延缓大鼠慢性肾衰的进程.
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| 关 键 词： | 蝉花菌丝体 慢性肾功能衰竭:肾切除 电灼 |
Effect of Cordyceps sobolifera Mycelium on Chronic Renal Failure in Rats |
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| XIE Wei,GUO Yuefang,SHENG Yuchen. Effect of Cordyceps sobolifera Mycelium on Chronic Renal Failure in Rats[J]. , 2011, 42(10) |
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| Authors: | XIE Wei GUO Yuefang SHENG Yuchen |
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| Affiliation: | XIE Wei,GUO Yuefang,SHENG Yuchen~* (Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437) |
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| Abstract: | Two kinds of rat model of chronic renal failure were established by 5/6 nephrectomy and electric cauterization to investigate the protective effect of Cordyceps sobolifera mycelium(CSM).The results showed that three dosage groups(0.6,1.2 and 2.4 g/kg) of CSM significantly inhibited the increase of serum urea nitrogen(BUN) level and creatinine(CRE) level in 5/6 nephrectomy rats and the increase of serum CRE level in electric cauterization rats.It indicated that CSM could reduce the rate of progression of chr... |
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| Keywords: | Cordyceps sobolifera mycelium chronic renal failure nephrectomy electric cauterization |
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