The effects of MPTP on the activation of microglia/astrocytes and cytokine/chemokine levels in different mice strains |
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Authors: | Yasuda Y Shimoda T Uno K Tateishi N Furuya S Yagi K Suzuki K Fujita S |
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Affiliation: | Cell Biology Section, Division of Basic Research, Louis Pasteur Center for Medical Research, 103-5, Sakyo-ku, Tanaka, Monzen-cho, Kyoto 606-8225, Japan. yyasuda@louis-pasteur.or.jp |
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Abstract: | The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-gamma, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP. |
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