| 环磷酰胺静脉冲击疗法治疗(氵弥)漫增殖型狼疮肾病疗效观察 |
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| 引用本文： | 周鸿烈,何威逊,罗运九,朱光华,任志德,方明俊. 环磷酰胺静脉冲击疗法治疗(氵弥)漫增殖型狼疮肾病疗效观察[J]. 临床儿科杂志, 1999, 0(2) |
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| 作者姓名： | 周鸿烈 何威逊 罗运九 朱光华 任志德 方明俊 |
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| 作者单位： | 上海市金山区中心医院儿科,上海市儿童医院,上海市儿童医院,上海市儿童医院,上海市儿童医院,上海市儿童医院 200040,200040,200040,200040,200040 |
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| 摘 要： | 狼疮肾是SLE重要并发症之一。如治疗不当常发展至终未性肾病(ESRD)。本文报告使用CTX静脉冲击疗法(CTX-PT)治疗(氵弥)漫增殖型狼疮肾病共7例。平均年龄7.6岁。CTX总量<150mg/kg。3例完全缓解,1例部份缓解,1例无效,经血浆置换术后缓解,1例发展为慢性肾功能衰竭,1例继续治疗中。作者结合LN临床及病理讨论CTX-PT的作用机制及疗效。
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| 关 键 词： | 环磷酰胺 狼疮肾病 肾病综合征 |
Therapeutic evaluation of CTX-PT for diffuse proliferative lupus nephritis |
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| Zhou Honglie,He Weixun. Luo Yunjiu,Zhu Guanghua,Ren Zhide,Fang Mingjun. Therapeutic evaluation of CTX-PT for diffuse proliferative lupus nephritis[J]. The Journal of Clinical Pediatrics, 1999, 0(2) |
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| Authors: | Zhou Honglie He Weixun. Luo Yunjiu Zhu Guanghua Ren Zhide Fang Mingjun |
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| Affiliation: | Zhou Honglie,He Weixun. Luo Yunjiu,Zhu Guanghua,Ren Zhide,Fang Mingjun. Shanghai Children's Hospital,Shanghai 200040 |
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| Abstract: | Lupus nephritis(LN) was one of the complications of systemic lupus erythematosus (SLE). and ending-stage renal disease(KSRD) would usually be developed following an improper treatment. CTX pulse therapy (CTX-PT) was here used in 7 cases with diffuse proliferative lupus nephritis at the average age of 7. 6 years. The total dosage of CTX in the course was less than 150mg/kg. The results showed that complete remission clinically was on 3 cases , partial remission on one case, ineffectiveness on one case and then got remission after exchange transfusion, one case developed chronic renal failure , and the last one was still on therapy. The action and therapeutic evaluation of CTX-PT were discussed in the present article. |
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| Keywords: | CTX lupus nephritis nephrotic syndrome |
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