| 肥胖大鼠肝脏、骨骼肌叉头状因子O1基因表达对胰岛素抵抗的影响 |
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| 引用本文： | 马晓君,秦贵军,闫晓洁,樊大贝,余勤,董义光.肥胖大鼠肝脏、骨骼肌叉头状因子O1基因表达对胰岛素抵抗的影响[J].中华糖尿病杂志,2009,17(7):519-521. |
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| 作者姓名： | 马晓君 秦贵军 闫晓洁 樊大贝 余勤 董义光 |
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| 作者单位： | 郑州大学第一附属医院内分泌科,450052 |
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| 基金项目： | 河南省医学科技攻关计划资助项目 |
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| 摘 要： | 目的观察肥胖大鼠肝脏和骨骼肌叉头状因子O1（FoxO1）的表达，探讨Fox01在肥胖和胰岛素抵抗发生中的作用。方法30只SD大鼠随机分为对照组（NC，常规饲料）和高脂组（HF，高脂饲料）。饲养10周后测定有关指标。结果10周后与NC组相比，HF组体重、血糖、胰岛素、TG、TC、腹内脂肪／体重均升高，肝脏和骨骼肌FoxO1mRNA表达量分别增加84％和88％（P〈0．01）。TG、HOMA-IR及腹内脂肪／体重是肝脏FoxO1mRNA表达的独立相关因素，HOMA-IR及腹内脂肪／体重是骨骼肌FoxO1表达水平的主要影响因素。结论肥胖大鼠肝脏和骨骼肌FoxO1表达量升高，可能是肥胖状态下引发胰岛素抵抗的机制之一。
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| 关 键 词： | 胰岛素抵抗 叉头状因子O1 大鼠 |
Effect of FoxO1 expressions of mRNA and protein on insulin resistance in liver and muscle tissues of obese rats |
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| Institution: | MA Xiao-jun , QIN Gui-jun , YAN Xiao-jie , et al. (Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052 ,China) |
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| Abstract: | Objective To investigate the effect of FoxO1 expressions of mRNA and protein on insulin resistance. Methods 30 SD rats were randomly divided into 2 groups： control （NC）, high-fat diet （HF）. The parameters were detected after feeding for 10 weeks. Results The body weight （BW）, visceral fat/body weight ratio （VF/BW）, FPG, Ins, TG, TC, and HOMA-IR index were significantly higher in HF group than in NC group. The mRNA levels of FoxO1 in liver and muscle of HF group were increased by 84 % and 88% respectively compared with NC group （P〈0.01）. TG, HOMA-IR and VF/ BW were independent factors influencing FoxO1 mRNA in liver（r^2 =0. 141, 0. 271, 0. 273, all P〈0. 01）, while HOMA-IR and VF/BW were independent variables of muscle FoxO1 mRNA expression（r^2 =0. 460, 0. 219, P〈0. 01）. Condusions The increased expression of FoxO1 in high-fat-fed rats is related to obesity and insulin resistance. |
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| Keywords: | Insulin resistance FoxO1 Rats |
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