| 中老年妇女骨转换生化指标和骨密度的变化 |
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| 引用本文： | 刘红,廖二元,伍贤平,张红,谢辉,曹行之. 中老年妇女骨转换生化指标和骨密度的变化[J]. 中华内分泌代谢杂志, 2009, 25(2). DOI: 10.3760/cma.j.issn.1000-6699.2009.02.010 |
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| 作者姓名： | 刘红 廖二元 伍贤平 张红 谢辉 曹行之 |
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| 作者单位： | 1. 湖南株洲市一医院代谢内分泌科工作,412001
2. 中南大学湘雅二医院代谢内分泌研究所,长沙,410011 |
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| 基金项目： | 卫生部临床学科重点项目 |
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| 摘 要： | 目的 探讨中老年妇女骨转换生化指标与骨密度随绝经的变化.方法 408名符合条件40 ～80岁的女性志愿者,同一时间段留取血清和晨尿,统一用酶免方法 测定血清骨碱性磷酸酶(BAP)、骨钙素和尿I型胶原氨基末端肽(uNTX);用舣能X线骨密度仪测定前后位腰椎1-4(L1-4)、左侧股骨颈的骨密度.结果 (1)BAP、骨钙素和uNTX与年龄、孕次、生育次数和绝经年限呈正相关(均P
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| 关 键 词： | 骨转换生化指标 骨密度 绝经 |
Changes of biochemical markers of bone turnover and bone mineral density in mid- and old-aged women |
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| LIU Hong,LIAO Er-yuan,WU Xian-ping,ZHANG Hong,XIE Hui,CAO Xing-zhi. Changes of biochemical markers of bone turnover and bone mineral density in mid- and old-aged women[J]. Chinese Journal of Endocrinology and Metabolism, 2009, 25(2). DOI: 10.3760/cma.j.issn.1000-6699.2009.02.010 |
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| Authors: | LIU Hong LIAO Er-yuan WU Xian-ping ZHANG Hong XIE Hui CAO Xing-zhi |
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| Abstract: | Objective To study the changes of biochemical markers of bone turnover and bone mineral density (BMD) in mid- and old-aged women.Methods A total of 408 female volunteers aged 40 to 86 years were enrolled.Serum bone alkaline phosphatase (BAP),osteoealtin and urine type I collagen N-telopeptide(uN'TX) were measured using ELISA,and BM D at anteroposterior lumbar spine 1-4(L1-4)and femoral neck (FN) was detected by dual energy X-ray absorptiometry (QDR4500A).Results (1) Serum BAP,osteocaltin and uNTX levels were positively correlated with age,parity,number of births and duration of menopause (all P
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| Keywords: | Biochemical markers of bone turnover Bone mineral density Menopause |
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