| 电针夹脊穴通过磷酸化p38 MAPK信号通路对大鼠炎性痛阈的影响 |
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| 引用本文： | 王航,黄浩,蔡克银. 电针夹脊穴通过磷酸化p38 MAPK信号通路对大鼠炎性痛阈的影响[J]. 安徽中医学院学报, 2010, 29(5): 34-37. DOI: 10.3969/j.issn.1000-2219.2010.05.013 |
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| 作者姓名： | 王航 黄浩 蔡克银 |
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| 作者单位： | 1. 中国人民解放军广州军区武汉总医院干部病房二科,湖北,武汉,430070
2. 华中科技大学同济医学院附属协和医院消化内科,湖北,武汉,430022 |
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| 摘 要： | 目的观察电针夹脊穴对炎性疼痛大鼠痛阂的影响，从信号转导的角度探讨针灸镇痛的机制。方法采用经典的完全弗氏佐剂性关节炎疼痛模型，观测电针刺激对大鼠痛阈的影响，采用免疫组织化学法测定各组大鼠背根神经节（doral root ganglion，DRG）内磷酸化p38丝裂原活化蛋白激酶（phosphorylation—p38 mitogen activated protein kinase，p-p38MAPK）的含量，采用蛋白印迹法测定DRG内辣椒素受体1（vanilloid receptor1，VR1）含量。结果电针刺激影响大鼠DRG内P—p38MAPK和VR1含量，并可提高炎性疼痛大鼠的痛阂，降低p38MAPK受体阻断剂提高后大鼠的痛闽。结论电针影响炎性疼痛的机制与p38MAPK—VR1信号通路密切相关。
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| 关 键 词： | 电针 背根神经节 磷酸化p38丝裂原活化蛋白激酶 |
Effects of Electroacupuncture at Jiaji Acupoints on Pain Threshold in Arthritis Rats by Phosphorylation p38 MAPK Signal Pathway |
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| WANG Hang,HUANG Hao,CAI Ke-yin. Effects of Electroacupuncture at Jiaji Acupoints on Pain Threshold in Arthritis Rats by Phosphorylation p38 MAPK Signal Pathway[J]. Journal of Anhui Traditional Chinese Medical College, 2010, 29(5): 34-37. DOI: 10.3969/j.issn.1000-2219.2010.05.013 |
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| Authors: | WANG Hang HUANG Hao CAI Ke-yin |
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| Affiliation: | WANG Hang1,HUANG Hao2,CAI Ke-yin1(1.Second Department of Geratology,Wuhan General Hospital of Guangzhou Comm,,Chinese PLA,Hubei Wuhan 430070,China,2.Division of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science & Technology.Hubei Wuhan 430022,China) |
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| Abstract: | Objective To observe the influence of electroacupuncture(EA) at Jiaji acupoints on the pain threshold in arthritis rats and investigate analgesic mechanism of EA by signal transduction pathway.Methods Arthritis rat model was induced with complete Freund's adjuvant(CFA).The effects of EA on pain threshold were observed.The contents of phosphorylation-p38 mitogen activated protein kinase(p-p38 MAPK) in the dorsal root ganglion(DRG) were determined using immunohistochemistry technology in all rats,and the expr... |
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| Keywords: | Electroacupuncture Dorsal root ganglion Phosphorylation p38 mitogen activated protein kinase |
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