| 肿瘤化学治疗药物的研究——9-胺基吖啶类化合物的合成 |
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| 引用本文： | 张葆珣,谢克勤,刘纪云.肿瘤化学治疗药物的研究——9-胺基吖啶类化合物的合成[J].药学学报,1980,15(1):40-45. |
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| 作者姓名： | 张葆珣 谢克勤 刘纪云 |
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| 作者单位： | 天津药物研究所
(张葆珣，谢克勤)，天津药物研究所(刘纪云) |
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| 摘 要： | 1942年Badger发现若干甲基苯骈吖啶化合物能抑制Walker 256癌肉瘤生长;Lewis和Goland实验证明了包括阿的平(Atebrin)在内的一些氨基取代的吖啶衍生物,对移植性小鼠肉瘤或乳癌生长具有抑制作用。由此胺基吖啶类化合物的抗肿瘤实验研究有了发展。1954年发现9-(3′-一二甲胺基丙胺基)吖啶抑制小鼠S_(180)作用后,波兰Ledóchowski等合成了大
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| 收稿时间： | 1979-02-14 |
STUDY ON CANCER CHEMOTHERAPY——SYNTHESIS OF 9-AMINOACRIDINE COMPOUNDS |
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| Zhang Baoxun,Xie Keqin and Liu Jiyun.STUDY ON CANCER CHEMOTHERAPY——SYNTHESIS OF 9-AMINOACRIDINE COMPOUNDS[J].Acta Pharmaceutica Sinica,1980,15(1):40-45. |
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| Authors: | Zhang Baoxun Xie Keqin and Liu Jiyun |
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| Abstract: | As certain compounds of acridine group were known to have anti-tumor effect in animal experiments and have been studied extensively, a number of 9-aminoacridine derivatives were prepared in this laboratory. The synthesis were carried out by direct condensation of 9-chloroacridine with pertinent amines in organic solvent, Results of animal screening revealed that compound 9-(p-methylanilino)-acridine was effective against mouse leukemia 615, Sarcoma 180, liver carcinoma (solid), lympho-sarcoma and other tumors when given orally. The compound had been recommended for clinical trial in 1976. |
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