Orthograde and retrograde axonal transport of dopamine-β-hydroxylase in ileal mesenteric nerves of rats with chronic streptozotocin diabetes |
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Authors: | Robert E Schmidt Christopher W Modert Gary G Grabau |
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Abstract: | Rats with chronic streptozotocin-induced diabetes develop a neuropathy involving the ileal mesenteric nerves. Distal portions of these postganglionic sympathetic axons develop markedly dilated, dopamine-β-hydroxylase (DBH)-containing dystrophic swellings. These findings led us to develop a quantitative method to examine orthograde and retrograde axonal transport of DBH in ileal mesenteric nerves. Surprisingly, no significant alteration in orthograde or retrograde axonal transport of DBH was identified. |
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Keywords: | Autonomic (sympathetic) neuropathy Diabetes Neuroaxonal dystrophy Dopamine-β -hydroxylase Axonal transport |
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