| 帕罗西汀联合丙戊酸镁缓释片治疗抑郁症的临床疗效观察 |
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| 引用本文： | 封正敏,刘波.帕罗西汀联合丙戊酸镁缓释片治疗抑郁症的临床疗效观察[J].中国健康心理学杂志,2011,19(1):6-7. |
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| 作者姓名： | 封正敏 刘波 |
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| 作者单位： | 中国.云南省楚雄州第二人民医院,675000 |
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| 摘 要： | 目的评价帕罗西汀联合丙戊酸镁缓释片治疗抑郁症的疗效及安全性。方法 100例符合CCMD-3抑郁症诊断的病人分为2组,分别给予帕罗西汀联合丙戊酸镁缓释片治疗（治疗组）和单用帕罗西汀治疗（对照组）,疗程均为8周。根据汉密尔顿抑郁量表（HAMD）减分率评定疗效,用副反应量表（TESS）评定用药的安全性,在治疗前和治疗后的1,2,4,6,8周末分别对2组进行评定。结果治疗组和对照组各50例,治疗组总的有效率为77.6%,对照组总有效率为51.2%。2组间,（HAMD）减分率疗效比较差异有统计学意义（t=3.089,P〈0.01）,不良反应的发生率：治疗组不良反应发生率为41%,对照组不良反应的发生率为40%,（TESS）评定两组比较无统计学差异（t=0.088,P〉0.05）;对照组中有8例有过躁狂发作（16.0%）,治疗组中只有1例有过躁狂发作（1.96%）,对照组转躁率高于治疗组,2组比较有统计学差异（t=2.582,P〈0.05）。结论帕罗西汀联合丙戊酸镁缓释片治疗抑郁症疗效可增强,起效快,安全性好。
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| 关 键 词： | 丙戊酸镁缓释片 帕罗西汀 抑郁症 |
Observation on Clinical Curative Effect of Paroxetine Combined with Magnesium Valproate Sustained Release Tablets in Treatment of Depression |
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| Feng Zhengmin,Liu Bo.Observation on Clinical Curative Effect of Paroxetine Combined with Magnesium Valproate Sustained Release Tablets in Treatment of Depression[J].china journal of health psychology,2011,19(1):6-7. |
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| Authors: | Feng Zhengmin Liu Bo |
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| Institution: | Feng Zhengmin,Liu Bo.The Second People's Hospital of Chuxiong State,Yunnan Province,Chuxiong State 675000,P.R.China |
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| Abstract: | Objective To evaluate the effect and safety of Paroxetine combined with Magnesium valproate sustained release tablets in treatment of depression.Methods A total of 100 patients who accorded with the diagnosis of depress in CCMD-3 were divided into 2 groups,and given Paroxetine conbined with Magnesium valproate sustained release tablets(treatment group) and Paroxetine alone(control group) respectively for 8 weeks.The effects were assessed with HAMD diameter reduction rate and the safeties were assessed with ... |
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| Keywords: | Magnesium valproate sustained release tablets Paroxetine Depression |
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