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| 人胎儿垂体生长激素的个体发生 | |
| 引用本文： | 卫朝霞,李杭生,张华,闫素云,张银合,周祥庭. 人胎儿垂体生长激素的个体发生[J]. 解剖学杂志, 2000, 23(4): 370-372 |
| 作者姓名： | 卫朝霞 李杭生 张华 闫素云 张银合 周祥庭 |
| 作者单位： | 1. 河南职工医学院解剖学教研室 2. 妇产科教研室,郑州,450003 3. 河南医科大学解剖教研室 |
| 摘 要： | 目的：了解胎儿生长激素合成和分泌的个体发生。方法：采用原位杂交化学方法测定２８例１６－３２周胎儿垂体生长激素信使核糖核酸（ＧＨｍＲＮＡ），用放射免疫分析法测定血清生长激素，甲状腺素、皮质醇和胰岛素的浓度。结果：（１）ＧＨｍＲＮＡ的含量随胎龄逐渐增加，到２４－２６周达高峰。（２）血清生长激素的浓度不恒定，有随胎龄增加而上升的趋势。（３）血清甲状腺素浓度和血清皮质醇的浓度与垂体生长激素ＧＨｍＲＮＡ含量 |
| 关 键 词： | 人胎儿 垂体生长激素 个体发生 |
ONTOGENY OF GROWTH HORMONE IN THE HUMAN FETAL PITUITARY |
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| Wei Zhaoxia,Li Hangsheng,Zhang Hua,Yan Suyun,Zhang Yinhe,Zhou Xiangting. ONTOGENY OF GROWTH HORMONE IN THE HUMAN FETAL PITUITARY[J]. Chinese Journal of Anatomy, 2000, 23(4): 370-372 | |
| Authors: | Wei Zhaoxia Li Hangsheng Zhang Hua Yan Suyun Zhang Yinhe Zhou Xiangting |
| Affiliation: | Wei Zhaoxia ,Li Hangsheng ,ZhangHua ,Yan Suyun ,Zhang Yinhe ,Zhou Xiangting ;(Department of Anatomy, Henan Stuff Medical College, Zhengzhou 450003) |
| Abstract: | To examine the ontogeny of growth hormone synthesis and secretion in human fetus. Methods: Growth hormone messenger ribonucleic acid (GHmRNA) was measured in 28 pituitary of fetuses from 16 to 32 weeks by in situ hybridization. Serum growth hormone, thyroxine, cortison and insulin concentrations were assessed by radio immunoassay. Results: (1)GHmRNA content in the fetal pituitary increased gradually with ages and reached a maximal level at 24 to 26 weeks. (2)Serum concentration of growth hormone was variable, (3)Serum concentration of thyroxine and serum concentration of cortison was correlated positively with growth hormone messenger ribonucleic acid, but no correlation with serum growth hormone concentration. Conclusion: The function of GH synthesis and secretion in the fetal pituitary become mature at about 24 weeks. old. Thyroxine and cortison may play role in the ontogenesis of growth hormone. |
| Keywords: | growth hormone human fetal pituitary |
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