坎地沙坦对老年慢性心力衰竭伴阵发性房颤患者P波最大时限及P波离散度的影响

目的探讨坎地沙坦对慢性心力衰竭伴阵发房颤患者P波最大时限（Pmax）及P波离散度（Pd）的影响。方法 51例慢性心力衰竭伴阵发性房颤患者被随机分为坎地沙坦治疗组（治疗组26例）和对照组（25例）,慢性心力衰竭基本治疗两组相同,治疗组加用坎地沙坦2～4mg/d,在治疗前、治疗后6个月分别测量Pmax和Pmin,计算出Pd（Pd=Pmax-Pmin）。结果治疗前两组Pmax和Pd比较无显著差异（P〉0.05）;治疗6个月治疗组的Pmax、Pd显著降低,与对照组相比有显著意义（P〈0.01）;而对照组治疗前后相比没有差异（P〉0.05）。治疗组房颤发作次数明显减少,与对照组比较差异有显著意义（P〈0.01）,结论坎地沙坦治疗慢性心力衰竭伴阵发性房颤患者可明显降低Pmax、Pd,减少房颤发作次数。

The effect of Candesartan on Pmax and Pd in chronic cardiac insufficiency patients with paroxysmal atrial fibrillation

Objective To investigate the effects of candesartan on Pmax and P wave dispersion（ Pd） in chronic cardiac insufficiency patients with paroxysmal atrial fibrillation（ PAF）. Methods 51 chronic cardiac insufficiency patients were randomly divided into candesartan treatment group（ treatment group.n = 26） and control group（ n = 25）. Basic treatment of chronic cardiac insufficiency in two groups was comparable. The pa-tients in treatment group were treated by candesartan 2 ～ 4 mg/d. Pmax and Pd were measured based on the 1 2-lead electrocardiogram at the beginning and at the six months after taking medicine. Results At the beginning there was no significant difference between two groups（ P〉 0. 05） ; Pmax and Pd were significantly decreased in treatment group after 6 months compared to that of control group （ P 〈0. 01） ; but it was not significant in control group （ P〉 0. 05）. PAF rate was decreased after 6 months treatment and compared to that of control group （ P 〈0. 01）. The difference was significant in control groups（ P〈 0. 01）. Conclusion Pmax and Pd were obviously decreased in chronic cardiac insufficiency patients with PAF. Candesartan can decrease PAF rate by decreasing Pmax and Pd.