| 中药丹参注射液对兔脊髓损伤的影响 |
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| 摘 要： |
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| 关 键 词： | 脊髓损伤 丹参注射液 丙二醛 超氧化物歧化酶 一氧化氮 动物实验 |
Protective effect of dansheng injection on experimental rabbits'' spinal cord injury] |
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| Jiang-dong Ni,Ren-kui Ding,Guo-hua Lü. Protective effect of dansheng injection on experimental rabbits'' spinal cord injury][J]. Bulletin of Hunan Medical University, 2002, 27(6): 507-508 |
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| Authors: | Jiang-dong Ni Ren-kui Ding Guo-hua Lü |
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| Affiliation: | Department of Orthopedic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. |
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| Abstract: | OBJECTIVE: To investigate the protective effect of Dansheng injection on experimental rabbits' in spinal cord injury. METHODS: Thirty-two New Zealand rabbits were impacted between T12-T1 with a force of 150 g.cm-1 (10 g x 15 cm). The rabbits were randomly divided into the injury group, monitor group, L-NAME group and Dansheng group. The blood was obtained at 0 h, 4 h, 6 h to separate the serum at the end the injured spinal cord. Cord tissues were obtained for histological examination. Methyl-di-aldehyde (MDA), superoxide dismutase (SOD) and nitro oxide (NO) from the serum and spinal tissues homogenated were tested. RESULTS: MDA and NO increased in the injury group compared with the others, but SOD significantly decreased in the injury group compared with the others. Histological examination showed that neurons were degenerated and necrosed. The injury group displayed serious changes while the Dansheng group less changes. iNOS expressed in all the groups. CONCLUSION: Dansheng injection has some protective effect on spinal cord injury in the early stage. |
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