| 2型糖尿病患者认知功能及海马氢质子磁共振波谱研究 |
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| 引用本文： | 周红,卢万俊,滕皋军,张志珺,吴旻. 2型糖尿病患者认知功能及海马氢质子磁共振波谱研究[J]. 中国医学影像技术, 2009, 25(8): 1367-1370 |
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| 作者姓名： | 周红 卢万俊 滕皋军 张志珺 吴旻 |
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| 作者单位： | 1. 东南大学附属中大医院神经内科,东南大学脑血管病研究所,江苏,南京,210009
2. 东南大学附属中大医院放射科,东南大学脑血管病研究所,江苏,南京,210009 |
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| 基金项目： | 国家重点基础研究计划973项目，国家自然科学基金 |
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| 摘 要： | 目的 探讨2型糖尿病(T2DM)患者与健康对照者(HC)认知功能与双侧海马代谢的异同.方法 应用多维度神经心理测试对比评估21例T2DM患者和19名HC的神经认知功能;并采用氢质子磁共振波谱(1H-MRS)检测双侧海马氮-乙酰天门冬氨酸复合物(NAA),胆碱复合物(Cho)与肌酸(Cr)的比值.结果 ①T2DM组听觉词语记忆测试-延迟回忆项(AVLT-delay recall)、听觉词语记忆测试-再认回忆项(AVLT-recognition)和画钟测试(CDT)成绩均显著地低于HC组(P均<0.05),并与糖化血红蛋白(HbAlc)呈负相关;②T2DM患者双侧海马NAA/Cr降低(均P<0.01),并以左侧为著(P<0.05);左侧海马Cho/Cr增高(P<0.05);③双侧海马代谢指标与T2DM患者BMI、FBG和HbAlc呈负相关;左侧海马NAA/Cr与AVLT-Delay Recall成绩正相关.结论 T2DM可引起海马代谢异常及多项认知功能损害,且左侧海马代谢异常可能与记忆损害密切相关.
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| 关 键 词： | 糖尿病 2型 认知 海马 磁共振波谱 |
| 收稿时间： | 2009-02-05 |
| 修稿时间： | 2009-04-17 |
The study of cognitive function and proton magnetic resonance spectroscopy on hippocampus in patients with type 2 diabetes mellitus |
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| ZHOU Hong,LU Wan-jun,TENG Gao-jun,ZHANG Zhi-jun and WU Min. The study of cognitive function and proton magnetic resonance spectroscopy on hippocampus in patients with type 2 diabetes mellitus[J]. Chinese Journal of Medical Imaging Technology, 2009, 25(8): 1367-1370 |
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| Authors: | ZHOU Hong LU Wan-jun TENG Gao-jun ZHANG Zhi-jun WU Min |
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| Affiliation: | Department of Neurology, Institution of Cerebral Vascular Disease, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China;Department of Neurology, Institution of Cerebral Vascular Disease, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China;Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China;Department of Neurology, Institution of Cerebral Vascular Disease, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China;Department of Radiology, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China |
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| Abstract: | |
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| Keywords: | Diabetes mellitus, type 2 Cognition Hippocampus Magnetic resonance spectroscopy |
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