大口径毛细管气相色谱法测定丙帕他莫中3种有机溶剂的残留量 |
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引用本文: | 王述蓉,罗宏丽,黄毅岚. 大口径毛细管气相色谱法测定丙帕他莫中3种有机溶剂的残留量[J]. 泸州医学院学报, 2011, 34(3): 278-279 |
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作者姓名: | 王述蓉 罗宏丽 黄毅岚 |
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作者单位: | 泸州医学院附属医院药剂科,四川泸州,646000 |
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摘 要: | 建立丙帕他莫中3种有机溶剂残留量的测定方法。方法:用大口径毛细管拄气柑色谱法,以外标法计算战留溶剂的含量。结果:3种有机溶剂均完全分离,乙醇、丙酮、二氯甲烷的线性范围分别为100.72~1007.2μg/ml(r=0.9997)、103.86~1038.6μg/ml(r=0.9996)、12.94~129.4μg/ml(r=0.9997),平均回收率分别为99.9%、99.5%、100.8%,P.SD分别为1.1%、1.3%、16%(n=5)。结论:所建方法灵敏、准确,可用于丙帕他莫中3种残留溶剂的同时测定。
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关 键 词: | 丙帕他莫 有机溶剂残留量 毛细管气相色谱 |
SIMULTANEOUS DETERMINATION OF 3 RESIDUAL ORGANIC SOLVENTS IN PROPACETAMOL BY LARGE DIAMETER CAPILLARY GC |
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Affiliation: | Wang Shurong,et al Department of Pharmacy,the Affiliated Hospital of Luzhou Medical College |
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Abstract: | To establish a method for determining 3 residual organic solvents in Propacetamol. Methods:Residual organic solvents were determined by large diameter capillary gas chromatography with external standardization. Results:3 compounds of residual organic solvents were separated completely.The standard curves of ethanol, acetone,and dichloromethane were linear in the ranges of 100.72-1007.2μg/ml (r=0.9997), 103.86- 1038.6pog/ml (r=0.9996),and 12.94-129.4μg/ml (r=0.9997), respectively; and the average recoveries were 99.9%, 99.5% and 100.8% with the RSD of 1.1% ,1.3% and 1.6% (rt=5), respectively. Conclusion:The method is sensitive, accurate and suitable for the determination of 3 residual organic solvents in pro~acetamol. |
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Keywords: | Propacetamol Residual Organic solvent Capillary Gas Chromatography |
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