原发性十二指肠癌核仁组成区嗜银蛋白的定量研究

用核仁组成区嗜银蛋白（ＡｇＮＯＲ）的银染色技术研究了３０例原发性十二指肠癌、２０例十二指肠溃疡及２０例正常十二指肠粘膜的ＡｇＮＯＲ计数变化，以探讨ＡｇＮＯＲ计数对原发性十二指肠癌的诊断价值。结果显示：十二指肠溃疡组与正常十二指肠粘膜组ＡｇＮＯＲ计数无显著差异（Ｐ＞０．０５），原发性十二指肠癌与十二指肠溃疡和正常粘膜比较ＡｇＮＯＲ计数有显著性差异（Ｐ＜０．００１），且低分比腺癌及粘液腺癌与高分化腺癌及乳头状腺癌比较ＡｇＮＯＲ计数也有显著者差异（Ｐ＜０．０５）。结果表明ＡｇＮＯＲ计数能较好反映原发性十二指癌的增殖活性，可以作为评价原发性十二指肠癌恶性程度的定量参数

A Quantitative Study of Argyrophilic Proteins of Nucleolar Organizer Region in Primary Duodenal Carcinoma

Using argyrophilic proteins of nucleolar organizer regions(AgNOR) silver staining technique, the AgNOR count was made in 30 specimens of primary duodenal carcinoma (PDC), 20 specimens of normal ducdenal mucosa (NDM) and 20 specimens of duodenal ulcer tissue (DUT).to investigate its value in the diagnosis of primary duodenal carcinoma. The results showed that AgNOR count of PDC was significantly higher than that of DNM and DUT (P<0 001),so was the AgNOR count of low differentiated adenocarcinoma and mucinous adenocarcinoma significantly higher than that of highly differentiated adenocarcinoma and papillocarcinoma (P<0 05). These findings suggested that the AgNOR count may reflect the proliferative activity of PDC, and may be used as a quantitative parameter for the assessment of degree of malignant PDC.