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| 丹红注射液对大鼠离体肠系膜动脉血管环作用及机制 | |
| 引用本文： | 智晓文,苏显明,封卫毅,张红梅.丹红注射液对大鼠离体肠系膜动脉血管环作用及机制[J].中国中药杂志,2012,37(17):2607-2611. |
| 作者姓名： | 智晓文 苏显明 封卫毅 张红梅 |
| 作者单位： | 1. 西安交通大学 医学院 第一附属医院老年心血管内科,陕西 西安,710061 2. 西安交通大学 医学院 第一附属医院药学部,陕西 西安,710061 3. 西安交通大学 生命与技术学院,陕西 西安,710049 |
| 基金项目： | 国家自然科学基金项目(60801057);陕西省中医药管理局项目(jc37) |
| 摘 要： | 目的:探讨丹红注射液对离体大鼠肠系膜动脉血管环的作用及作用机制.方法:采用离体血管环实验方法,经生物信号采集与分析系统测定血管环张力的变化.结果:丹红注射液对血管基础张力无影响；能明显舒张去甲肾上腺素(norepinephrine,NE)预收缩的完整内皮血管,去内皮后对该作用无明显影响；能明显舒张高钾预收缩的血管；对咖啡因预收缩血管作用无明显影响；能抑制NE诱导的内钙释放及外钙内流；钾通道阻滞剂对丹红注射液的舒张作用无影响.结论:丹红注射液有明显的扩血管作用,主要通过血管平滑肌起作用,其机制可能为抑制受体、电压依赖的外钙内流和IP3受体介导的内钙释放而舒张血管. |
| 关 键 词： | 丹红注射液 肠系膜动脉 大鼠 |
| 收稿时间： | 2011/10/29 0:00:00 |
Effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats |
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| ZHI Xiao-wen,SU Xian-ming,FENG Wei-yi and ZHANG Hong-mei.Effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats[J].China Journal of Chinese Materia Medica,2012,37(17):2607-2611. | |
| Authors: | ZHI Xiao-wen SU Xian-ming FENG Wei-yi and ZHANG Hong-mei |
| Institution: | Department of Geriatric Cardiology, First Affiliated Hospital of Medicine College of Xi'an Jiaotong University, Xi'an 710061, China;Department of Geriatric Cardiology, First Affiliated Hospital of Medicine College of Xi'an Jiaotong University, Xi'an 710061, China;Department of Pharmacy, First Affiliated Hospital of Medicine College of Xi'an Jiaotong University, Xi'an 710061, China;The School of Life Science and Technology of Xi'an Jiaotong University, Xi'an 710049, China |
| Abstract: | Objective: To study the effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats. Method: An isolated vascular ring experiment was conduced to determine the changes in tension of vascular rings with a biological signal collection and analytical system. Result: Danhong injection had no impact on the tension of vascular rings. Danhong injection showed a significant vasodilatation effect on treated arteria rings of norepinephrine, and no remarkable impact was made on the effect without endothium. It showed notable effect on blood vessels treated with Ca2+ and no significant impact on those treated with caffeine. It could inhibit NE-induced intracellular calcium from releasing and external calcium from inflowing. No effects of potassium channel blockers on aorta ring tensile force were found. Conclusion: Danhong injection shows significant vasodilation effect, which mainly works through vascular smooth muscle. Its vasodilation effect may be related to inhibitory receptor, voltage-dependent Ca2-release and IP3 receptor-mediated Ca2+-influx. |
| Keywords: | Danhong injection mesenteric arterial ring rat |
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