| 大叶茜草中环肽类成分的研究 |
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| 引用本文： | 邝彬,范君婷,赵思蒙,谭宁华. 大叶茜草中环肽类成分的研究[J]. 中国中药杂志, 2012, 37(17): 2563-2570 |
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| 作者姓名： | 邝彬 范君婷 赵思蒙 谭宁华 |
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| 作者单位： | 1. 中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室,云南 昆明 650201;中国科学院研究生院,北京 100049
2. 中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室,云南 昆明,650201 |
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| 基金项目： | 国家自然科学基金项目(91013002,30725048);国家自然科学基金-云南联合基金项目(U1032602);国家重大新药创制科技重大专项(2011ZX09307-002-02);国家重点基础研究发展计划(937)项目(2009CB522300);中国科学院项目(KSCX2-EW-R-15) |
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| 摘 要： | 目的:对大叶茜草Rubia schumanniana根茎中环肽类化合物进行分离和鉴定.方法:大叶茜草根茎的70％甲醇回流提取物经硅胶,RP-18,Sephadex LH-20和HPLC等色谱技术分离纯化,根据波谱数据鉴定化合物的结构.结果:分离得到9个环肽类化合物,分别鉴定为RA-Ⅶ(1),RA-Ⅴ(2),RA-Ⅻ (3),rubiyunnanin C (4),RA-Ⅹ(5),RY-Ⅱ(6),RA-Ⅰ(7),RA-ⅩⅢ(8),RA-ⅩⅢ-OMe(9).结论:9个环肽化合物均为首次从大叶茜草中分离得到.
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| 关 键 词： | 大叶茜草 环肽 |
| 收稿时间： | 2012-02-09 |
Cyclopeptides from Rubia schumanniana |
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| KUANG Bin,FAN Jun-ting,ZHAO Si-meng and TAN Ning-hua. Cyclopeptides from Rubia schumanniana[J]. China Journal of Chinese Materia Medica, 2012, 37(17): 2563-2570 |
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| Authors: | KUANG Bin FAN Jun-ting ZHAO Si-meng TAN Ning-hua |
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| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;Graduate University of Chinese Academy of Sciences, Beijing 100049, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;Graduate University of Chinese Academy of Sciences, Beijing 100049, China;State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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| Abstract: | Objective: To separate and identify cyclopeptides of tubers of Rubia schumanniana.Method: The 70% methanol extracts from tubers of Rubia schumanniana were separated and purified by silica gel,RP-18,Sephedax LH-20 and HPLC.Their structures were identified by spectral analysis.Result: Nine cyclopeptides were separated and identified as RA-Ⅱ(1),RA-V(2),RA-Ⅷ(3),rubiyunnanin C(4),RA-X(5),RY-Ⅱ(6),RA-Ⅰ(7),RA-XIII(8) and RA-XIII-OMe(9),respectively.Conclusion: All of nine cyclopeptides were separated from R.schumanniana for the first time. |
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| Keywords: | Rubia schumanniana cyclopeptide |
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