| 胃癌及癌前病变中P57~(KIP2)和PCNA的表达 |
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| 引用本文： | 卢书明,张竹青,刘丽娜,王朝晖,李梅,吕申.胃癌及癌前病变中P57~(KIP2)和PCNA的表达[J].胃肠病学和肝病学杂志,2010,19(11). |
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| 作者姓名： | 卢书明 张竹青 刘丽娜 王朝晖 李梅 吕申 |
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| 作者单位： | 大连医科大学附属第一医院消化内科;大连市中心医院病理科;大连医科大学附属第二医院中心实验室; |
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| 摘 要： | 探讨P57KIP2和PCNA在胃癌及癌前病变中的表达及意义。方法采用免疫组织化学技术SP法,检测P57KIP2和PCNA在57例胃癌(GC)、7例不典型性增生(Dys)、16例肠上皮化生(IM)、15例慢性萎缩性胃炎(CAG)及10例慢性浅表性胃炎(CSG)中的表达情况,并分析与胃癌临床病理之间的关系。结果P57KIP2在GC、Dys、IM、CAG、CSG中阳性表达率分别为43.9%、57.1%、81.3%、80.0%、80.0%,GC和Dys组的P57KIP2阳性表达率明显低于IM、CAG、CSG组(P均0.05);PCNA在GC、Dys、IM、CAG、CSG组阳性表达率分别为80.7%、85.7%、75.0%、46.7%、30.0%,GC、Dys、IM组PCNA表达率明显高于CAG、CSG组(P0.05);P57KIP2和PCNA均与胃癌组织分化程度相关(P0.05),而与淋巴结转移、浸润、临床分期无显著相关性(P0.05)。结论在胃黏膜癌变过程中,P57KIP2蛋白的失活不是一个早期基因事件,随着病变进展PCNA表达逐渐增加,P57KIP2蛋白表达下降和PCNA的表达增高可能在胃癌的发生发展中起重要作用,两者共同检测有助于胃癌恶性程度的判定。
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| 关 键 词： | P57KIP2 PCNA 胃癌 癌前病变 免疫组织化学技术 |
Expression of P57KIP2 and PCNA in gastric carcinoma and precancerous lesion |
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| LU Shuming,ZHANG Zhuqing,LIU Lina,WANG Zhaohui,LI Mei,LV Shen.Expression of P57KIP2 and PCNA in gastric carcinoma and precancerous lesion[J].Chinese Journal of Gastroenterology and Hepatology,2010,19(11). |
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| Authors: | LU Shuming ZHANG Zhuqing LIU Lina WANG Zhaohui LI Mei LV Shen |
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| Institution: | LU Shuming1,ZHANG Zhuqing2,LIU Lina1,WANG Zhaohui3,LI Mei3,LV Shen3 1. Department of Gastroenterology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,2. Department of Pathology,Dalian Municipal Central Hospital,3. Department of Central Laboratory,the Second Affiliated Hospital of Dalian Medical University,China |
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| Abstract: | Objective To observe the expression of P57KIP2 and PCNA in gastric carcinoma and precancerous lesion. Methods The expression of P57KIP2 and PCNA were examined in 57 cases of the gastric carcinoma,16 cases of intestinal metaplasia,7 cases of dysplasia,15 cases of chronic atrophic gastritis and 10 cases of chronic superficial gastritis tissues by immunohistochemical technology. Results The positive rates of P57KIP2 protein in gastric carcinoma,dysplasia, intestinal metaplasia,chronic atrophic gastritis and ch... |
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| Keywords: | P57KIP2 PCNA Gastric carcinoma Precancerous lesion Immunohistochemistry |
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