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Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
Authors:Marschall Hanns-Ulrich  Wagner Martin  Zollner Gernot  Fickert Peter  Diczfalusy Ulf  Gumhold Judith  Silbert Dagmar  Fuchsbichler Andrea  Benthin Lisbet  Grundström Rosita  Gustafsson Ulf  Sahlin Staffan  Einarsson Curt  Trauner Michael
Affiliation:Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. hanns-ulrich.marschall@medhs.ki.se
Abstract:
Keywords:4β-OH-C, 4β-hydroxy cholesterol   BAAT, bile acid amino transferase   BSEP, bile salt export pump   C4, 7α-hydroxy-4-cholesten-3-one   CA, cholic acid   CYP, cytochrome P450   DCA, deoxycholic acid   HCA, hyocholic acid   LCA, lithocholic acid   CDCA, chenodeoxycholic acid   HDCA, hyodeoxycholic acid   MDR, multidrug resistance protein   MRP, multidrug resistance-related protein   OATP, organic anion transporting polypeptide   PBC, primary biliary cirrhosis   RIFA, rifampicin   UGT, uridine diphosphate glucuronosyltransferase   UDCA, ursodeoxycholic acid
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