实验性脑弥漫性轴索损伤急性期病理改变与临床症状的关系

目的 通过动物实验研究，探讨弥漫性轴索损伤的病理改变及临床症状的相关关系。方法 用自行设计的加速机对36只猫从冠状位分别以不同的角加速度转动造成损伤。结果主要的病理表现为：蛛网膜下腔出血、硬膜下／外血肿、胼胝体损伤；皮层下及白质区可见多发针尖样出血灶。光镜下见：轴索扭曲、肿胀、断裂、轴索收缩球出现及轴索问条带样的问质水肿。结论 DAI是一种闭合性原发性颅脑损伤。DAI的确认主要有赖于病理观察。

The Relationships between Pathologic Changes in Acute Phase of Experimental Diffuse Axonal Injury and Its Clinical Symptoms

Objective To explore pathological changes in acute phase of experimental diffuse axonal injury (DAI) and the relations with its clinical symptoms.Methods Experimental models of DAI were made in 36 cats by a self designed acceleration machine. Results The pathological examination were made in 3,24,48 and 72 hours respectively after injury. The main pathological changes of DAI included axonal torsion, swelling and breaking; the presence of axonal retraction balls(ARB) and callus injury, hemorrhagic spots in subcortical areas and white matter of brain on the gross specimen.Conclusions DAI was one primary and close brain injury, and its diagnosis should be depended on pathological examination.