人脑膜瘤IGF-1表达及其意义

目的探讨人脑膜瘤组织中胰岛素样生长因子-1（IGF-1）的表达及其意义。方法收集人脑膜瘤标本110例,其中WHOⅠ、Ⅱ和Ⅲ级分别为70、22和18例;另收集正常脑膜标本12例作为对照组。采用免疫组化染色法分析IGF-1、增殖细胞核抗原（PCNA）和第Ⅷ因子相关抗原（FⅧ-RAg）表达情况。结果脑膜瘤组织中IGF-1、PCNA、FⅧ-RAg表达水平较正常硬脑膜组织明显增高（P〈0.05）;随着脑膜瘤WHO级别增高,IGF-1、PCNA、FⅧ-RAg表达水平亦明显增高（P〈0.05）。同一级别脑膜瘤组织中,IGF-1、PCNA、FⅧ-RAg两两之间均呈显著正相关（P〈0.05）。结论人脑膜瘤组织中IGF-1的表达强弱与脑膜瘤血管生成、细胞增殖活性有关。

Insulin-like growth factor 1 expression in human meningiomas and its meanings

Objective To explore the expression of insulin-like growth factor 1 （IGF-1） in the human meningiomas and its meanings. Methods The expressions of the IGF-1, proliferating cell nucleus antigen （PCNA） and FV Ⅲ factor related antigen （FV Ⅲ -Rag） [to determine microvascular density （MVD）] in 110 cases of human meningiomas, of which, 70 were WHO grade Ⅰ , 22 WHO grade Ⅱ, and 18 WHO grade Ⅲ, and 12 samples of normal dura mater of brain were determined by immunohistochemical technique. Results The levels of IGF-1 and PCNA expressions were significantly higher in WHO grade Ⅲ meningioma that those in WHO grade II meningiomas （P〈0.05）, which were significantly higher than those in WHO grade Ⅰ meningiomas （P〈0.05）, which were significantly higher than those in the normal dura mater of brain （P〈0.05）. The value of MVD was significantly higher in WHO grade Ⅲ meningiomas that those in WHO grade II and I meningiomas （P〈0.05）, which were significantly higher than that in the normal dura mater of brain （P〈0.05）. The levels of IGF-1, PCNA and FVI-RAg （i.e. MVD） were positively related to WHO grade of the meningiomas （P〈0.05）. Conclusion It is suggested that IGF-1 may be involved in the pathogenesis and development of the meningiomas.