| 塞来昔布水凝胶的制备及质量评价 |
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| 引用本文： | 宋艳红,张友智. 塞来昔布水凝胶的制备及质量评价[J]. 解放军药学学报, 2014, 0(5): 392-395 |
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| 作者姓名： | 宋艳红 张友智 |
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| 作者单位： | 武汉科技大学附属天佑医院,湖北武汉430064 |
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| 摘 要： | 目的制备塞来昔布水凝胶并对其质量进行评价。方法以壳聚糖为凝胶基质,以月桂氮酮和油酸为透皮吸收促进剂,制备外用凝胶;采用HPLC法测定塞来昔布含量。结果该法制得的水凝胶饱和溶胀度、黏附性好,刺激性小;含量测定方法准确可靠。结论该方法可用于塞来昔布水凝胶的制备和质量控制。
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| 关 键 词： | 水凝胶 塞来昔布 壳聚糖 合理配方 质量评价 |
Preparation and Quality Evaluation of Celecoxib Hydrogels |
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| SONG Yan-hong,ZHANG You-zhi. Preparation and Quality Evaluation of Celecoxib Hydrogels[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2014, 0(5): 392-395 |
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| Authors: | SONG Yan-hong ZHANG You-zhi |
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| Affiliation: | ( Tianyou Hospital, Wuhan University of Science and Technology, Wuhan 430064, China) |
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| Abstract: | Objective To prepare celecoxib hydrogels and assess the quality. Methods Celecoxib hydrogels for external use were prepared using chitosan as the base, laurocapram and oleic acid as the skin penetration enhan- cer. The drug content was determined by HPLC. Results The preparation had a good saturated swelling degree, strong adhesiveness, and little excitation. Conclusion This method can be used in the preparation and quality control of celecoxib hydrogels. |
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| Keywords: | hydrogels celecoxib chitosan optimized formula quality evaluation |
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