围术期应用抑肽酶减少脑肿瘤手术出血及脑水肿的临床研究(附60例分析)

目的　对围术期应用抑肽酶减少脑肿瘤手术出血及脑水肿进行前瞻性研究。方法　将 6 0例择期手术病人随机分为 2组 ,每组 30例。实验组术前 12h至术后 2 4h内连续给药 ,抑肽酶剂量为 7× 10 3 KIU/kg ,加入林格氏液中静滴。对照组单纯使用等容量林格氏液静滴。结果　实验组出血和脑水肿明显减轻 ,两组对比手术出血量和脑水肿有极显著差异 (P <0 .0 1)。结论　围术期应用抑肽酶可明显减少脑肿瘤手术出血及脑水肿 ,有较好的止血作用

Clinical study of using aprotinin during perioperation to decrease hemorrhage during operation of brain neoplasms and brain edema

Objective　To make prospective study about using aprotinin during perioperation to decrease hemorrhage during operation of brain neoplasms and brain edema.Methods　Sixty patients (ASA grade Ⅰ-Ⅱ) were allocated randomly to two groups,each group 30 patients.Test group,aprotinin (7×103KIU/kg) and Ringer's liquid were persistently imported with intravenous drip from 12h before operation till 24h postoperatively.Control groups, Ringer's liquid without aprotinin was persistently imported with intravenous drip.Results　Hemorrhage quantity and brain edema in test group were obviously decreased.Hemorrhage quantity and brain edema between two groups had significant meaning in statistics(P<0.01).Conclusion　Using aprotinin during perioperation can obviously decrease hemorrhage during operation of brain neoplasms and brain edema,and it has better hemostasis effect.