调节性T淋巴细胞与缺血性卒中 |
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引用本文: | 陈祥,叶丹,徐运.调节性T淋巴细胞与缺血性卒中[J].国外医学:脑血管疾病分册,2013(12):933-937. |
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作者姓名: | 陈祥 叶丹 徐运 |
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作者单位: | 南京大学医学院附属鼓楼医院神经内科, 210008 |
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摘 要: | 卒中是一种高致死率和高致残率的脑血管病类型,其中缺血性卒中约占80%.目前认为,炎症机制在缺血性卒中的病理生理学进展中发挥重要作用.外周T淋巴细胞在脑缺血后24 h内浸润受损区域,参与脑组织炎症过程的进展.作为T淋巴细胞的一个亚群,调节性T细胞主要定位于缺血半暗带,但目前对其在缺血性脑损伤中的作用仍存在着争议.研究调节性T细胞在脑缺血中的作用机制,有助于进一步认识缺血性卒中的发病机制和发现新的治疗靶点.
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关 键 词: | 卒中 脑缺血 T-淋巴细胞 调控 炎症 |
Regulatory T lymphocytes and ischemic stroke |
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Institution: | CHEN Xiang, YE Dan, XUN Yun |
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Abstract: | Stroke is a cerebrovascular disease type with high morbidity and mortality,of which ischemic stroke accounts for about 80%.Now,it is believed that the inflammatory mechanisms play an important role in the progress of pathological physiology of ischemic stroke.Peripheral T lymphocytes infiltrate to the damaged area within 24 hours after cerebral ischemia and are involved in the advance of inflammatory process of brain tissue.As a subtype of T lymphocytes,regulatory T cells are mainly located in the ischemic penumbra; however,at present,its role in ischemic brain injury remains controversial.The research on the mechanisms of regulatory T cells in ischemic stroke may contribute to further understanding of the pathogenesis of ischemic stroke and find new therapeutic targets. |
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Keywords: | Stroke Brain Ischemia T-Lymphocytes Regulatory Inflammation |
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