| CD40/CD40L系统与动脉粥样硬化 |
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| 引用本文： | 王毓婧,刘亚民. CD40/CD40L系统与动脉粥样硬化[J]. 国外医学:脑血管疾病分册, 2013, 0(12): 947-952 |
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| 作者姓名： | 王毓婧 刘亚民 |
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| 作者单位： | 西安交通大学第一附属医院脑血管病科, 710061 |
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| 摘 要： | 动脉粥样硬化是一种慢性炎症性疾病.动脉粥样硬化斑块破裂和血栓形成可导致急性心脑血管事件.炎性介质CD40/CD40L广泛存在于与动脉粥样硬化相关的细胞,参与斑块内炎症反应,释放促炎细胞因子,降解细胞外基质,提高促凝活性,促进动脉粥样硬化的进展和斑块易损性.干预CD40/CD40L信号系统可能成为减缓动脉粥样硬化进展和稳定动脉粥样硬化斑块的一种有效治疗策略.
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| 关 键 词： | 抗原,CD40 CD40配体 动脉粥样硬化 炎症 Antigens,CD40 |
CD40/CD40L system and atherosclerosis |
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| WANG Yu-jing,LIU Ya-min. CD40/CD40L system and atherosclerosis[J]. Foreign Medical Sciences Cerebrovascular Diseases, 2013, 0(12): 947-952 |
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| Authors: | WANG Yu-jing LIU Ya-min |
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| Affiliation: | WANG Yu-jing, LIU Ya-min |
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| Abstract: | Atherosclerosis is a chronic inflammatory disease.Atherosclerotic plaque rupture and thrombosis may result in cardio-cerebrovascular events.Inflammatory mediator CD40L widely exists in cells associated with atherosclerosis.They participate in plaque inflammatory response,release proinflammatory cytokines,degrade extracellular matrix,improve procoagulant activity,and promote the progression of atherosclerosis and plaque vulnerability.Intervening CD40/CD40L signaling system may become an effective treatment strategy to slow the progress of atherosclerosis and stabilize atherosclerotic plaques. |
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| Keywords: | CD40 Ligand Atherosclerosis Inflammation |
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