| 小胶质细胞Toll样受体2与脑缺血 |
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| 引用本文： | 陈灵丽,任明山.小胶质细胞Toll样受体2与脑缺血[J].国外医学：脑血管疾病分册,2013(10):792-795. |
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| 作者姓名： | 陈灵丽 任明山 |
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| 作者单位： | 安徽医科大学附属省立医院神经内科,合肥230001 |
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| 摘 要： | 急性脑缺血后,小胶质细胞被迅速激活,发挥神经修复和神经毒性的双刃剑作用.近年来的研究表明,小胶质细胞的这种双重作用可通过Toll样受体2（Toll-like receptor 2,TLR2）信号转导通路来实现.因此,合理调控小胶质细胞TLR2表达有可能在一定程度上提高对脑缺血的干预效果.文章对TLR2在脑缺血中的作用机制以及可能的干预措施进行了综述.
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| 关 键 词： | 类Toll受体2 脑缺血 小胶质细胞 |
Microglial Toll-like receptor 2 and cerebral ischemia |
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| CHEN Ling-li,REN Ming-shan.Microglial Toll-like receptor 2 and cerebral ischemia[J].Foreign Medical Sciences Cerebrovascular Diseases,2013(10):792-795. |
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| Authors: | CHEN Ling-li REN Ming-shan |
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| Institution: | 1.Department of Neurology, Anhui Provincial Hospital Affiliate to Anhui Medical University,Hefei 230001, China;) |
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| Abstract: | Microglia can be activated immediately after acute cerebral ischemia and play a role of double-edged sword of nerve repair and neurotoxicity.Studies in recent years have suggested that this dual role of microglia can be achieved by a Toll-like receptor 2 （TLR2） signal transduction pathway.Therefore,reasonable regulation of TLR2 expression of microglia may improve the therapeutic effect of cerebral ischemia to a certain extent.This article reviews the mechanisms of TLR2 in cerebral ischemia and the possible interventions. |
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| Keywords: | Toll-Like Receptor 2 Brain Ischemia Microglia |
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