Chemical constituents from the roots and stems of Litsea cubeba |
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Authors: | Qiang Guo Rui-Feng Bai Guo-Zhu Su Zhi-Xiang Zhu Ke-Wu Zeng |
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Affiliation: | 1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China;2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China;3. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100191, China |
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Abstract: | A new monoterpene and a new lignan, named litsecols A and B (1 and 2), respectively, together with nine known compounds (3–11), were isolated in a continuous investigation on the roots and stems of Litsea cubeba. Their structures were elucidated on the basis of extensive spectroscopic data analysis, and the absolute configuration of 1 was resolved by X-ray diffraction analysis. Compounds 2–5 and 7–9 showed significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine microglial (Bv-2) cell line. Compounds 10 and 11 exhibited significant neuroprotective effect against hydrogen peroxide-induced oxidative damage in rat adrenal pheochromocytoma (PC12) cell line. |
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Keywords: | Litsea cubeba Lauraceae anti-inflammatory activity neuroprotective effect |
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