Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method |
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| Authors: | Fengzhi Xu Tianqi Zhao Shurong Wang Songfeng Liu Ting Yang Zhanfeng Li |
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| Affiliation: | 1. College of Chemistry, Jilin University, Changchun, P. R. China;2. Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, P. R. China |
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| Abstract: | Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morphology with the average size of 2?μm. The microcapsules showed an excellent magnetic property. In addition, the pH-responsive controlled release of coumarin 6 (C6) from MPRCMCs indicated that the developed microcapsules could be a promising candidate for drugs carriers. |
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| Keywords: | Drug delivery chitosan microcapsules magnetic pH-responsive sonochemistry |
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