Effects of sodium nitroprusside on mouse erythrocyte catalase activity and malondialdehyde status |
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| Authors: | Mamane Sani Hichem Sebai Roberto Refinetti Mohan Mondal Néziha Ghanem-Boughanmi Naceur A. Boughattas |
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| Affiliation: | 1. Département De Biologie, Faculté Des Sciences Et Techniques De Maradi, UMR Biosurveillance Et Toxicologie Environnementale, Maradi, Niger,;2. Circadian Rhythm Laboratory, Boise State University, Boise, ID, USA, sanimamane@yahoo.fr;4. Département Des Sciences De La Vie, UR Ethnobotanie Et Stress Oxydant, Zarzouna, Tunisia,;5. Circadian Rhythm Laboratory, Boise State University, Boise, ID, USA,;6. National Dairy Research Institute, Kalyani, West Bengal, India,;7. Laboratoire De Pharmacologie, Faculté De Médecine, Monastir, Tunisia, and |
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| Abstract: | There is controversy about the anti- or pro-oxidative effects of the nitric oxide (NO)-donor sodium nitroprusside (SNP). Hence, the activity of the antioxidant enzyme catalase (CAT) and the status of malondialdehyde (MDA) were investigated after a 2.5?mg/kg dose of SNP had been i.p. administered to different and comparable groups of mice (n?= 48). The drug was administered at two different circadian times (1 and 13 h after light onset [HALO]). There were, irrespectively of sampling time, no significant differences in the means of CAT activity and MDA status between control and SNP-treated groups, no matter the treatment time. However, CAT activity was significantly (Student’s t-test, p?p?F0.05(7,88)=?5.3; p?
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| Keywords: | Catalase malondialdehyde mouse sodium nitroprusside erythrocyte |
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