An update on repurposed medications for the treatment of drug-resistant tuberculosis |
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Authors: | Arnold Mafukidze Elizabeth Harausz |
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Institution: | 1. Clinical Services Department, University Research Corporation, LLC, Mbabane, Swaziland;2. U.S. Military HIV Research Program, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA |
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Abstract: | Introduction: Drug-resistant forms of tuberculosis are a major public health problem with a serious global impact. Although there have recently been two new drugs introduced for the treatment of drug-resistant TB (bedaquiline and delamanid), the current therapeutic armamentarium is limited. Because treatment of drug-resistant TB requires the use of a multidrug-regimen, there has been growing interest in the use of antibiotics developed for other infectious pathogens but that have shown efficacy in the treatment of TB.Areas covered: This paper will review these ‘re-purposed’ agents – including the beta-lactams, clarithromycin, clofazimine, the fluoroquinolones, and linezolid – with a focus on their efficacy, safety, and pharmacokinetic properties.Expert commentary: There is growing evidence on the efficacy and safety of repurposed drugs for the treatment of drug-resistant TB, supporting their program-wide inclusion in treatment regimens as recommended in revised WHO guidelines. However, additional work is needed to define optimum dosing as well as describe their role in regimen optimization. |
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Keywords: | Tuberculosis drug resistance repurposed drugs beta lactams clofazimine clarithromycin linezolid fluoroquinolones |
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