Four new diterpenoids isolated from the Euphorbia rapulum |
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| Authors: | Xiao-Xue Liu Lei Shang Chao Huang Xue-Song Feng Wen Li Yi Sha |
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| Affiliation: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. School of Pharmacy, China Medical University, Shenyang 110122, China;3. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Four new diterpenoids named 1-epi-9-hydroxydepressin (1), 1-epi-8-hydroxydepressin (2), 2,13,9-trihydroxy-labda-8(17),12(E),14-triene (3) and tagalsin I (4) were isolated from Euphorbia rapulum. The structures of these compounds were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for cytotoxic activities against HepG2, MCF-7, and C6 cell lines, and compound 4 showed moderate selective activity against MCF-7 cell line with an IC50 value of 31.8 μM. |
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| Keywords: | Euphorbiaceae Euphorbia rapulum diterpenoids cytotoxic activities |
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