Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy for the treatment of primary peritoneal serous carcinoma: Results of a Chinese retrospective study |
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Authors: | Jian-Hua Sun Kai-Wen Peng Hai-Tao Wu Qian Zhang Yukata Yonemura |
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Institution: | 1. Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumour Biological Behaviours and Hubei Cancer Clinical Study Centre, Wuhan, China;2. Department of Gastrointestinal Surgery, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, China;3. liyansd2@163.com;5. NPO Organization to Support Peritoneal Dissemination Treatment, Osaka, Japan |
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Abstract: | Purpose Primary peritoneal serous carcinoma (PPSC) is a rare condition with a poor survival rate, even after treatment with debulking surgery followed by systemic chemotherapy. This study evaluated the efficacy and safety of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of PPSC.Patients and methods This retrospective study included 22 female patients with primary advanced PPSC (group A, n?=?12) or recurrent PPSC (group B, n?=?10) treated with 25 CRS?+?HIPEC procedures. The primary end point was overall survival (OS), and the secondary end points were safety profiles.Results A total of 25 CRS?+?HIPEC procedures were performed in these 22 patients. The median OS was 31.0 months (95% confidence interval (CI) 22.3–39.7), and the 1-, 3-, and 5-year survival rates were 100%, 45.5%, and 27.3%, respectively. Subgroup analyses revealed that the median OS was 31.0 months (95% CI 19.8–42.2) for group A vs. 38.5 months (95% CI 9.6–67.4) for group B (P?=?0.832, log rank test); 51.5 months (95% CI 34.9–68.1) for peritoneal cancer index (PCI)?≤?15 vs. 20.3 months (95% CI 12.6–28.0) for PCI > 15 (P?=?0.000, log rank test); and 38.5 months (95% CI 22.5–54.5) for completeness of cytoreduction (CC) of 0–1 vs. 23.5 months (95% CI 15.3–31.7) for CC of 2–3 (P?=?0.178, log rank test). There were no perioperative deaths. Serious adverse events (SAEs) occurred in two patients (9.1%). A univariate analysis identified PCI ≤ 15 as the only prognostic predicator (hazard ratio (HR) 13.1, 95% CI 2.7–63.4, P?=?0.001).Conclusions CRS?+?HIPEC could contribute to favourable outcomes for select PPSC patients with acceptable safety profiles. |
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Keywords: | Cytoreductive surgery hyperthermic intraperitoneal chemotherapy primary peritoneal serous carcinoma |
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