Elbasvir and grazoprevir for chronic hepatitis C genotypes 1 and 4 |
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| Authors: | Mohamed El Kassas Tamer Elbaz Yasmeen Abd El Latif Gamal Esmat |
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| Affiliation: | 1. Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egyptm_elkassas@yahoo.com;3. Endemic Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, Egypt;4. Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt |
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| Abstract: | Introduction: During the last few years, treatment of hepatitis C virus (HCV) revolutionized with the appearance of direct antiviral agents especially for patients with HCV genotypes 1 and 4 infections. Elbasvir (NS5A inhibitor) and grazoprevir (NS3/4A protease inhibitor) are newly developed drugs that are presented in fixed dose combination tablets.Areas covered: This review covers the mechanism of action, pharmacokinetic and pharmacodynamics properties, clinical uses, safety and efficacy of elbasvir/grazoprevir in managing a wide variety of easy and difficult to treat populations (such as presence of cirrhosis, treatment experienced, co-infection with HIV and patients with inherited blood disorders).Expert commentary: Elbasvir/grazoprevir combination showed great efficacy with high rates of sustained virological response rates in genotypes 1 and 4 HCV infection. In addition, it retained a good safety profile and is generally well tolerated. |
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| Keywords: | HCV genotype 1 genotype 4 elbasvir and grazoprevir |
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