Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer |
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Authors: | Yueling Yuan Xi Xia Ronghua Zhang |
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Institution: | College of Pharmacy, Jinan University, Guangzhou, P. R. China, |
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Abstract: | Breast cancer is a serious threat to women's health, because multidrug resistance (MDR) has hampered treatment and prognosis. Nanodelivery of anticancer agents is a new technology to be exploited in the treatment of patients, because it bypasses multispecific drug efflux transporters such as P-glycoprotein (ABCB1), multidrug resistance protein-1 (MRP1, ABCC1) and breast cancer resistance protein (BCRP, ABCG2). Drugs can be delivered to tumor tissue by passive and active tumor targeting strategies, which may reduce or reverse drug resistance. This review will mainly focus on MDR-associated proteins, as well as various nanoparticle formulations developed to overcome MDR in breast cancer. |
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Keywords: | Breast cancer mechanisms multidrug resistance nanoparticles |
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