Serum nitrate and NOx levels in preeclampsia are higher than in normal pregnancy |
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| Authors: | Breno José Acauan Filho Bartira Ercilia Pinheiro da Costa Patrícia Barcelos Ogando Matias Costa Vieira Ivan Carlos Antonello Carlos Eduardo Poli-de-Figueiredo |
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| Affiliation: | 1. Programa de Pós-Gradua??o em Medicina e Ciências da Saúde, Instituto de Pesquisas Biomédicas – Hospital S?o Lucas/Faculdade de Medicina of Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazilbart@pucrs.br;3. Programa de Pós-Gradua??o em Medicina e Ciências da Saúde, Instituto de Pesquisas Biomédicas – Hospital S?o Lucas/Faculdade de Medicina of Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil |
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| Abstract: | Objectives: To compare nitric oxide (NO) serum levels in women with and without preeclampsia. Methods: 106 women were classified into preeclampsia group (n = 40) and normotensive group (n = 66). NO content was measured in the serum. Clinical and laboratorial data were recorded for comparison. Results: Preeclampsia presented a significant increase in nitrate and NOx levels compared to the control group. Uric acid, gestational age, systolic and diastolic blood pressure, and creatinine showed correlation with nitrates and NOx. Conclusion: Increase of NO was observed in preeclampsia women. Failure in the mechanism of action, dependent on cyclic GMP, may justify this finding. |
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| Keywords: | Cyclic GMP endothelium-dependent relaxing factors hypertension nitrite pregnancy-induced vasodilatation |
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