Two new glycosides from Dryopteris fragrans with anti-inflammatory activities |
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| Authors: | Bing Peng Rui-Feng Bai Ping Li Xu-Yang Han Hong Wang Chong-Chong Zhu |
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| Affiliation: | 1. Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China;2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | Phytochemical investigation on the aqueous extract from Dryopteris fragrans led to the isolation of one new chromone glycoside, frachromone C (1), and one new coumarin glycoside, dryofracoulin A (2), together with one known undulatoside A (3). Their structures were elucidated by a combination of 1D and 2D NMR, HRMS, and chemical analysis. Compounds 1–3 exhibited inhibition on nitric oxide production in lipopolysaccharide induced RAW 264.7 macrophages with their IC50 values of 45.8, 65.8, and 49.8 μM, respectively. |
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| Keywords: | Dryopteridaceae Dryopteris fragrans isolation structure elucidation anti-inflammatory activity |
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