Drug targeting to arthritic region via folic acid appended surface-engineered multi-walled carbon nanotubes |
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| Authors: | Jitendra Kayat Virendra Gajbhiye Narendra Kumar Jain |
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| Affiliation: | 1. Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India,;2. Center for Nanobioscience, Agharkar Research Institute, Pune, Maharashtra, India;3. Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India,;4. Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India, and |
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| Abstract: | This study was aimed at developing and investigating folate anchored carbon nanotubes for targeting an anti-arthritic drug, Methotrexate (MTX) to inflammatory arthritic region. The folic acid (FA) was conjugated to amidated multi-walled carbon nanotubes (MWCNTs) and confirmed by Fourier transform infrared (FTIR), 1H NMR spectroscopy and X-ray diffraction analysis. The MTX was loaded into the pristine and functionalized-MWCNTs and extensively characterized in vitro and in vivo studies. The drug entrapment efficiency was found high in folate conjugated MWCNTs. In vitro drug release in PBS (pH 7.4) from pristine MWCNTs and folate conjugated MWCNTs formulation was found to be 66.35?±?2.3 and 56.88?±?1.9% in 24?h, respectively. Folate conjugated MWCNTs significantly increased (p?in vivo biodistribution studies, MTX was found to be significantly higher (p?
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| Keywords: | Arthritic region folate methotrexate multi-walled carbon nanotube targeting |
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