Novel anionic polymer as a carrier for CNS delivery of anti-Alzheimer drug |
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| Authors: | Satya Lavanya Jakki K. Gowthamarajan V. Senthil Kunal Jain Sumeet Sood |
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| Affiliation: | 1. Department of Pharmaceutics, JSS College of Pharmacy, Off Campus J.S.S. University, Mysore, Udhagamandalam, Tamil Nadu, India, jslavanya@gmail.com;3. Department of Pharmaceutics, JSS College of Pharmacy, Off Campus J.S.S. University, Mysore, Udhagamandalam, Tamil Nadu, India,;4. Scientific Writer, Novartis Healthcare Pvt. Ltd, Hyderabad, Andhra Pradesh, India,;5. Scientific Writer, Indegene Lifesystems Pvt. Ltd, Bengaluru, Karnataka, India, and |
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| Abstract: | Natural and plant-based polymers could be used for control release of drugs and also helps in targeting drug to the site of action. The main objective of present work was to check the feasibility of plant-based, namely, mango gum polymeric nanoparticles (NPs) as a carrier for central nervous system (CNS) delivery using model drug donepezil (DZP). The NPs were prepared by modified ionic gelation method and emulsion cross-linking method. Zeta sizer results showed that the diameter of NPs was about 90–130?nm. The polymeric DZP-loaded NPs were almost spherical in shape, as revealed by transmission electron microscopy (TEM). On increasing concentration of NPs suspension from 50?μg/ml to 5000?μg/ml there was no significant increase in % hemolysis. In vivo studies showed that brain targeting was achieved. So on the basis of above results, the extracted water soluble fraction of mango gum is a suitable candidate for brain delivery in the form of nanoformulations. |
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| Keywords: | Biodistribution studies cytotoxicity donepezil plant polymer targeted delivery |
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