Highly oxygenated triterpenoids from the roots of Schisandra chinensis and their anti-inflammatory activities |
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Authors: | Qiu-Yan Song Zhi-Biao Nan |
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Affiliation: | State Key Laboratory of Grassland Agro-ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730020, China |
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Abstract: | A new highly oxygenated triterpenoid, schinchinenlactone D (1), and three known compounds (2–4) were isolated from the roots of Schisandra chinensis. Their structures were determined by combining the spectroscopic analysis with the theoretical computations. The anti-inflammatory activities of compounds 1–4 were evaluated, and compound 3 exhibits the most significant activity in the inhibition of NO production with an IC50 value of 10.6 μM. |
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Keywords: | Schisandraceae Schisandra chinensis highly oxygenated triterpenoids anti-inflammatory activity |
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