Highly oxygenated triterpenoids from the roots of Schisandra chinensis and their anti-inflammatory activities

A new highly oxygenated triterpenoid, schinchinenlactone D (1), and three known compounds (2–4) were isolated from the roots of Schisandra chinensis. Their structures were determined by combining the spectroscopic analysis with the theoretical computations. The anti-inflammatory activities of compounds 1–4 were evaluated, and compound 3 exhibits the most significant activity in the inhibition of NO production with an IC₅₀ value of 10.6 μM.