The Role of the IL-12 polymorphism rs3212227 in preeclampsia in Chinese Han Women |
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| Authors: | Xibing Wang Mingzhen Guo Sai Li Jianfeng Gong Weiqing Song |
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| Affiliation: | 1. Obstetrical Department, Maternal and Child Health Care of Zaozhuang, Zaozhuang, China;2. Department of Blood Transfusion, The Affiliated Hospital of Qingdao University, Qingdao, China;3. Biology Department, The Medical College of Qingdao University, Qingdao, China;4. Department of Clinical Laboratory, Chongqing Health for Women and Children, Chongqing, China;5. Department of Clinical Laboratory, Qingdao Municipal Hospital (Group), Qingdao, China |
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| Abstract: | Objective: To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women. Methods: We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR–restriction fragment length polymorphism. Results: No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ2 = 4.62, p = 0.10 by genotype; χ2 = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups. Conclusion: Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women. |
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| Keywords: | Genetics IL-12 polymorphism preeclampsia susceptibility |
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