Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb |
| |
| Authors: | Jian-Bo Yang Li Li Zhong Dai Yu Wu Xing-Chao Geng Bo Li |
| |
| Institution: | 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;2. National Institutes for Food and Drug Control, China Food and Drug Administration, Beijing 100050, China;3. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China;4. National Institutes for Food and Drug Control, China Food and Drug Administration, Beijing 100050, China |
| |
| Abstract: | Four new dianthrone glycosides, named polygonumnolides C1-C4 (1–4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5–6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1–4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35?μM, respectively. |
| |
| Keywords: | Polygonum multiflorum dianthrone glycosides polygonumnolides C1–C4 L-02 cell lines |
|
|
