Four new taraxastane-type triterpenoic acids from Cirsium setosum |
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| Authors: | Na Luan Wen-Di Wei Ali Wang Xiu-Li Wu Yan Qi Jin-Jie Li |
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| Institution: | 1. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China;2. College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China;3. Beijing Municipal Bureau of City Administration and Law Enforcement, Beijing 101500, China |
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| Abstract: | Four new taraxastane-type triterpenoids acids 3β,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3β-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments (1H-1HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 μM. |
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| Keywords: | Compositae Cirsium setosum taraxastane-type triterpenoids acids absolute configuration cytotoxic activities |
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